Food Business Network News The research paper published in the Journal of Clinical Endocrinology and Metabolism on August 4, 2016 clearly states that soy isoflavones have potential health benefits for women with polycystic ovary syndrome (PCOS). PCOS is an endocrine disorders characterized by high sex hormones and insulin. It is closely related to weight gain, infertility and increased risk of coronary heart disease. This disorder plagues 5-6 million women and their lives in the United States.
In this randomized, controlled trial, 70 women between the ages of 18 and 40 with PCOS were randomly assigned to supplement the 50 mg soy isoflavone supplement or placebo group daily for 12 weeks. At the beginning and end of the experiment, the researchers collected blood samples from the women tested and analyzed them to detect hormone levels, lipids, inflammatory markers, and insulin resistance in the subjects before and after supplementation. In addition, during the study period, the researchers asked the women to maintain normal exercise activities and to avoid taking other nutritional supplements as much as possible.
The study data showed that compared with the placebo group, the insulin and insulin resistance markers were decreased in the women in the supplemented soy isoflavone supplement group, insulin sensitivity increased, and plasma glutathione increased in the body, androgen, The levels of triglycerides and malondialdehyde are reduced.
The study's first author, Dr. Zatallah Asemi from Kashan University in Iran, said the study found that women with PCOS could benefit from the absorption of soy isoflavones through diet. Studies have found that biomarkers in women who regularly ingest soy isoflavones have a significant improvement, reflecting the effectiveness of the body's use of insulin to treat sugars and reduce harmful cholesterol levels.
Dr. Asemi added that the results have led to an increasing interest in how to add soy to the diet, and the study also showed that regular intake of soy isoflavones helps women with PCOS improve their metabolism and cardiovascular health. To address metabolic syndrome and other related health problems.
However, the researchers also raised some limitations of the study. For example, there is a lack of dose-response relationship test between soy isoflavone intake and metabolic indicators and oxidative stress changes; when it comes to soy isoflavone intake, the researchers did not have estrogen levels and other inflammatory effects in the subjects. And changes in oxidative stress markers were evaluated; moreover, the researchers used an enzyme-linked immunosorbent assay (ELISA) to measure testosterone and other steroid levels, rather than using liquid chromatography-mass spectrometry (known as chemistry) "Gold standard" in the measurement method).
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