Scientists solve the drug delivery needs by genetically modifying the intestinal flora
[China Pharmaceutical Network Technology News] Recently, researchers at the University of Florida have transformed a class of microorganisms called Lactobacillus paracasei. These modified probiotics secrete specific proteins and are expected to treat high blood pressure. In the study, it achieved very good results.
If you are ill, you need to take medicine to relieve symptoms and treat the disease. However, oral swallowing pills are not always the best way to deliver certain drugs: the acidic environment of the digestive tract (especially the stomach) can make the drug unstable. In addition, it takes a certain amount of time for the body to absorb the drug.
Is there a way to overcome these challenges and address the corresponding drug delivery needs?
The scientists thought of the neighbors in our body, the intestinal flora. By genetically modifying them, we can let them "produce" drugs. In this way, can we not be self-sufficient? This is not a whimsical thought. Previously, scientists have successfully designed microorganisms that produce vitamin A to effectively overcome obesity. But after obesity, only a few people will get it.
Are there any diseases that affect many people and can be cured by microorganisms?
The researchers turned their attention to high blood pressure. Recently, researchers at the University of Florida have engineered a class of microorganisms called Lactobacillus paracasei. These modified probiotics secrete specific proteins and are expected to treat high blood pressure. In the study, it achieved very good results. The researchers divided the experimental mice into three groups: one group had "hypertension" and was treated with probiotics. The other group, although suffering from "hypertension", only received treatment with common bacteria. The third group did not receive any treatment. Four weeks later, the researchers found that mice receiving "probiotics" had lower blood pressure, reduced wall thickness, and increased cardiac contractility. In other words, their high blood pressure is well controlled. The remaining two groups of mice did not show such good results at all. At the recent "American Heart Association Hypertensive Diseases Council Meeting," researchers reported their results and received a lot of praise. Dr. Mohan Raizada, a professor of physiology at the University of Florida, said: "In the treatment of high blood pressure, probiotics have long had some important advantages over traditional medicine."
In the production process, the drug needs to face the problems of processing production process and compound purity. The modified intestinal microbes are easy to 'produce' and are easy to take. The joke said that taking medicine later may be like eating yogurt. Recently, the United States launched the National Microbiome Program to further strengthen research in this area. We believe that new methods of treating diseases with microorganisms will become more and more in the future.
If you are ill, you need to take medicine to relieve symptoms and treat the disease. However, oral swallowing pills are not always the best way to deliver certain drugs: the acidic environment of the digestive tract (especially the stomach) can make the drug unstable. In addition, it takes a certain amount of time for the body to absorb the drug.
Is there a way to overcome these challenges and address the corresponding drug delivery needs?
The scientists thought of the neighbors in our body, the intestinal flora. By genetically modifying them, we can let them "produce" drugs. In this way, can we not be self-sufficient? This is not a whimsical thought. Previously, scientists have successfully designed microorganisms that produce vitamin A to effectively overcome obesity. But after obesity, only a few people will get it.
Are there any diseases that affect many people and can be cured by microorganisms?
The researchers turned their attention to high blood pressure. Recently, researchers at the University of Florida have engineered a class of microorganisms called Lactobacillus paracasei. These modified probiotics secrete specific proteins and are expected to treat high blood pressure. In the study, it achieved very good results. The researchers divided the experimental mice into three groups: one group had "hypertension" and was treated with probiotics. The other group, although suffering from "hypertension", only received treatment with common bacteria. The third group did not receive any treatment. Four weeks later, the researchers found that mice receiving "probiotics" had lower blood pressure, reduced wall thickness, and increased cardiac contractility. In other words, their high blood pressure is well controlled. The remaining two groups of mice did not show such good results at all. At the recent "American Heart Association Hypertensive Diseases Council Meeting," researchers reported their results and received a lot of praise. Dr. Mohan Raizada, a professor of physiology at the University of Florida, said: "In the treatment of high blood pressure, probiotics have long had some important advantages over traditional medicine."
In the production process, the drug needs to face the problems of processing production process and compound purity. The modified intestinal microbes are easy to 'produce' and are easy to take. The joke said that taking medicine later may be like eating yogurt. Recently, the United States launched the National Microbiome Program to further strengthen research in this area. We believe that new methods of treating diseases with microorganisms will become more and more in the future.
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