Japanese scientists have developed new ways to screen cancer cells
The research team of the researcher of the Institute of Physical Chemistry of Japan, Tanaka Kedian et al., successfully identified cancer cells and normal cells by using the principle that propargyl ester containing propargyloxy group can selectively react with polyamines in cancer cells.
There are more than 20 kinds of polyamines in mammalian cells, such as spermine, spermidine, putrescine and the like. The concentration of the polyamine is strictly controlled within a certain level by its synthesis and decomposition and movement inside and outside the cell. A positively charged polyamine combines with a normally negatively charged RNA to facilitate the synthesis of nucleic acids and proteins.
It is generally believed that polyamines are indispensable for cell division and proliferation. Excessive polyamines are produced in proliferating cancer cells. The concentration of polyamines in some cancer cells may even be as high as millimolar (mM). Therefore, polyamines The concentration in the cells can be used as a biomarker for identifying cancer cells. If the polyamine in the cell can be selectively reacted, the relevant cancer cells can be identified and a method for inhibiting the proliferation of the cancer cells can be found.
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