30-year-old global youth leader scientist: using genetic editing to overcome the problem of organ transplantation
On March 16, the World Economic Forum named the 2017 Global Youth Leaders list, and Dr. Yang Wei, who is only 30 years old, was selected. Her biotechnology company eGenesis, which she co-founded with her mentor, also announced that she has received $38 million in financing and is expected to use the CRISPR-Cas9 gene editing technology to overcome a major problem in human organ transplantation. These two great news have made Yang Lan a hot topic. Focus.
Yang Wei graduated from Peking University in 2008, and then went to Harvard University to obtain a master's degree. He studied under the "Gene Editing Big Cow" Professor of the American Academy of Sciences and Engineering, Professor George Church, and worked on the CRISPR-Cas9 gene editing system. In 2014, she and Professor George Church founded eGenesis's biotechnology company to promote the clinical application of xenotransplantation. The first to use the CRISPR-Cas9 technology to modify the cell genome and lead eGenesis, Yang Hao was named 2014 by Forbes Magazine. One of the 30 leading figures in the scientific and medical field under the age of 30.
In October 2015, Harvard University and biotechnology company eGenesis announced that it has integrated a CRISPR-Cas9 system into pig kidney epithelial cells using a new gene editing technology that continuously produces Cas9 protein and destroys the genome. All endogenous retroviral genes knock out viral genes that may be harmful in the pig genome. According to statistics, there are as many as 62 edited sites in the single genome. In subsequent experiments, the researchers found that this treatment prevented the replication of all viral copies, thereby preventing the virus from infecting human cells.
As a leader, Yang Lan said that this work has removed the biggest safety barrier in this field after discovering pig endogenous retrovirus more than 10 years ago. It has also rekindled everyone's confidence in xenotransplantation. Millions of patients who need organ transplants bring hope.
With this round of financing, the Yang Lan team plans to use a powerful genome editing platform to create a safe and effective xenotransplantation program for the benefit of patients in need, and let the medical community know the feasibility of xenotransplantation as soon as possible.
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