Why take aspirin to prevent colon cancer?

Why take aspirin to prevent colon cancer?

April 17, 2015 Source: Bio Valley

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Recently, Chinese scientists from the United States published their online research on the molecular mechanism of taking aspirin to prevent colon cancer in the international academic journal ebiomedicine.

Epidermal growth factor receptor (EGFR) is overexpressed in approximately 80% of colon cancer patients, so EGFR may play an important role in the pathogenesis of colon cancer. In the study, the researchers found that COX-2 upregulates the expression of EGFR in a family of multiple adenomas (FAP) and may therefore play an important role in the development of intestinal tumors, and COX-2 has long been considered The direct targeting of aspirin action, so the researchers conducted a study on whether aspirin can inhibit colon cancer by regulating EGFR expression.
The researchers immunohistochemically stained adenomatous polyps in normal human colonic mucosa, FAP patients taking aspirin, and FAP patients who did not take aspirin. It was found that EGFR was overexpressed early in colon cancer, whereas conventional aspirin can be used extensively. Reduce EGFR expression. More importantly, both EGFR and COX-2 are overexpressed in FAP patients and intracellular colocalization occurs. Further studies on the mechanism revealed that overexpression of COX-2 triggers activation of the c-Jun-dependent transcription factor AP-1, and AP-1 further binds to the EGFR promoter, resulting in the accumulation of EGFR in the cell to promote cancer.
The study found that aspirin may have a preventive effect on colon cancer, and this effect may be achieved by regulating EGFR expression.

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