The first "artificial kidney" that can produce urine
Release date: 2018-02-13
The University of Manchester professors Professor Sue Kimber and Adrian Woolf created the world's first kidney to produce urine in living tissue, marking an important milestone in the development of kidney disease treatment. This scientific advancement is published in Stem Cell Reports.
After 12 days of 2D culture, the human "micro-organ" derived from human embryonic stem cells has taken shape.
The glomeruli are part of the kidney. The researchers soaked the human embryonic stem cells in a medium containing molecules that promote kidney development. The cells were combined with gelatinous substances that mimic natural connective tissue and injected into the skin of mice. Form a small mass. Three months later, the tissue developed into the basic unit of nephrons, the basic unit of kidney structure and function.
This structure consists of most of the human kidney components, such as the proximal tubule, the distal tubule, the Bowman's capsule, and the Hai's sheath. Human capillaries that nourish the tissue are also developed in mice.
However, the miniature kidney still lacks a large artery to perform its full function, so the researchers are working with surgeons to try to insert an artery into it to get more blood nourishment.
In this study, in order to test the structure and function of the new "kidney", the team used a fluorescent protein called dextran (Dextran) in combination with a urine-like substrate to detect the "urine" produced by the kidneys after filtering the blood. Liquid (ie glomerular filtrate).
Transplanted into the skin of mice, the tissue continues to develop and begins to produce "urine"
“The results undoubtedly show that these structures have the function of filtering blood and producing urine, although for the time being we are unable to quantify their efficiency,†Professor Kimber said.
"Excitingly, these structures made up of human cells connect with the circulatory system in mice, providing good capillary blood supply to the entire tissue. Currently it is only a few hundred glomeruli, and human kidneys are about There are 1 million, but this is already a great progress, and we still have a lot of work to do," Professor Kimber said.
Professor Woolf said: "More than 2 million patients worldwide are undergoing kidney dialysis or kidney transplant treatment. Unfortunately, more than 2 million people who cannot receive treatment die every year from kidney failure. We hope that our research will one day Helping more patients get rid of the disease. Before that, there is still a lot of knowledge to learn. Based on the current kidney filtration unit, we also need to develop a matching urinary tract and turn this technology into a disease treatment plan. ."
Original title
Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors
Source: Biopass
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