Skin transplantation gene therapy can reduce sugar and lose weight
Release date: 2017-08-16
According to the latest issue of Cell·Stem Cell, US researchers provide a “conceptual validation†for a novel gene therapy via skin grafting, which can be used to treat two very common and interrelated human diseases: II Type 2 diabetes and obesity.
Researchers at the University of Chicago have used CRISPR technology to modify the glucagon peptide (GLP1) receptor gene. The GLP1 receptor gene stimulates the pancreas to secrete insulin, removes excess blood sugar from the blood, and prevents diabetic complications. At the same time, GLP1 can delay gastric emptying and reduce appetite.
The researchers extended the half-life of the GLP1 receptor gene in the blood in a specific way and incorporated the modified gene into an antibody fragment to allow it to run longer in the blood. In addition, they have added an inducible promoter that allows them to open genes as needed to produce more GLP1. The researchers then inserted the gene into the skin cells for culture and growth. When cultured cells are exposed to the air/liquid interface in the laboratory, they stratify, producing multiple layers of "skin-like organs." When transplanting laboratory-grown, genetically modified skin to mice with intact immune systems, the researchers did not find significant rejection.
The study also found that when eating foods containing traces of doxycycline, mice release dose-dependent levels of GLP1 into the bloodstream, thereby increasing blood insulin supply and lowering blood glucose levels.
On the other hand, when fed normal and genetically modified mice with high-fat foods, both quickly gain weight and become obese. Adding different levels of doxycycline while feeding high-fat foods can induce GLP1 release, and normal mice become obese; while genetically modified mice gain less weight gain. The researchers found the same effect when transplanting genetically modified human cells into mice with a limited immune system. This suggests that GLP1-induced skin gene therapy can be used for the prevention and treatment of diet-induced obesity and other diseases.
It is said that this combination of in vitro precise gene editing and efficient application of engineered cells in vivo will provide a long-term safe option for the treatment of many human diseases, such as replacement of patients with genetic defects (hemophilia). Loss of protein, or act as a metabolic library to eliminate toxins in the body.
Source: Technology Daily
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