"Science" in the United States to restart the bacteriophage antibacterial clinical trial - how to avoid entering the wolves?
Author: Xu Click to view more of his autobiography
This week's "US center will fight infections with viruses,Kelly Servick,Science" Â 22 Jun 2018: Vol. 360, Issue 6395, pp. 1280-1281) The story is as follows: In 2015, psychologist Tom Patterson of the University of California, San Diego, developed a rapid bacterial infection after returning from a holiday in Egypt. After getting into his spleen, he fell into a coma. After trying all the available antibacterials failed, his epidemiologist, who was a colleague at the same school, was in a hurry to seek out different kinds of phage for her husband's bacteria from some biological companies, university laboratories and government agencies in the United States. Infection treatment.
With the miraculous recovery of Tom Patterson, the antibacterial treatment that seems to have been negated and forgotten has returned to people's horizons. The US government also invested in San Diego to carry out the corresponding bacteriophage antibacterial clinical trial.
Retrospective attempts by humans to use bacteriophage for antibacterial therapy were first attempted by the Soviets, but they have not been able to go clinical except for the development of the world's most terrible biological weapon. Because the biggest obstacle to this method is the safety problem. One is that it is difficult to achieve specific attack on a certain kind of bacteria by phage. Second, the bacteria is too fast, and the design/production of phage is difficult to cope with.
Other tricky questions are, how do you control the spread of the phage itself without causing a biological disaster? Experiments have shown that phage kills harmful bacteria in the human body, such as beneficial bacteria in the intestines.
I have mentioned in the previous article: NMT non-invasive micro-test technology can help scientists screen new antibiotics. So can NMT also help us to screen more specific phage? And because of the rapid screening ability of NMT , can the phage screening speed catch up with the speed of mutation?
In view of the huge application risk of antibacterial phage, should we prepare sophisticated weapons and equipment, such as NMT technology , and then open the "war" against drug resistance? ! Otherwise, we are bound to have 'just out of the tiger's mouth, and into the wolves! 'risks of.
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references
The Revival of Phage Therapy to Fight Antimicrobial Resistance – Part I: What are the legal implications?
The author's blog posts on NMT non-invasive micro-test technology , regenerative medicine and micro-environment research are as follows:
Regenerative Medicine and NMT Non-Invasive Micro-Test Technology (2) China Opportunity
The effect of "Science" cancer drug treatment depends on the nutrient microenvironment: taboo is very important!
"Science" cancer immunotherapy is not unexpectedly frustrated: China's opportunity?
The Difficulties and Outlets of Resistance in Science: Opportunities in China?
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Veterinary drugs mainly include: serum products, microecological products, Chinese herbal medicines, proprietary Chinese medicines, chemicals, antibiotics, and topical pesticides, disinfectants, etc.
Veterinary Drugs,Veterinary Medicine,Veterinary Injectable Drugs,Veterinary Pharmaceutical Drugs
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