Common mouse species in experimental animal research

Who in the experimental animal community has contributed the most to humanity? I will vote for a mouse, and many of the research fields are inseparable from the contribution of mice. To the highest respect for those who have dedicated themselves to our human health!

Experimental animals are mainly used as animal models of diseases. Generally, the genetic background is clear or the source is clear, and it is mainly divided into inbred lines and closed groups. Today we talked about the common experimental mice.

Immunodeficient mice, recently very hot

Nude mouse

I don’t know who made our hair, and it’s not long after birth. Congenital immunodeficiency , no thymus, T cell defects . Spontaneous diseases, no one can blame. Growth and development are not good , and the fertility is certainly not as good as that of healthy mice. Although there are normal B lymphocytes, but they have functional defects, they have been used as models for human tumor and immunodeficiency disease research. Has the highest qualification in immunodeficient mice.

SCID mouse

SCID mice came to report and cough. When you are young, you have an immunodeficiency syndrome. The well-developed human diagnosis of autosomal recessive mutations (scid), the loss of T cells and B cells, and spontaneous tumors, so our family's body is very bad, in a highly clean It can survive for more than one year in the SPF environment. It is very difficult to live. It is because of our poor immunity that human beings can make us strong, saying that we are suitable for cell transplantation and tumor transplantation.

NOD-scid mouse

To ask me what is different from SCID mice, we actually backcrossed SCID (severe combined immunodeficiency) with non-obese diabetic mice (NOD/Lt). But our fate is even more tragic: in addition to the innate immune deficiency , there are also the loss of T and B lymphocytes , which is more suitable for the transplantation of various tumor cells .

B-NDG mice

Is there worse than me in severely immunodeficient mice? On NOD- background scid mice, again to my IL2rg gene knocked out, cruel! The function of T cells, B cells and NK cells is missing , and the results are very suitable for transplanting tumors . The time is fast, the cost is low, and the tumor formation rate is top! It is said to be particularly suitable for transplantation and growth of human hematopoietic stem cells and peripheral blood mononuclear cells. The CDX modeling rate is so high! It is no different from American big NSG and Japanese big cow NOG. The only difference is that we are domestic, national, and own brand, support!

Severe immunodeficiency: nude mice

Engraftment of human tumors and immune systems in strains of immunodeficient mice

Leonard D. Shultz, 2014

Common inbred mice

BALB/c mice

Hello everyone, my name is BALB/c mice, which has been famous for making monoclonal antibodies to plasma cell hybridomas grow in vivo. Since humans have injected mineral oil, we have somehow developed plasmacytoma. Therefore, research on oncology, immunology and inflammation has been linked to us.

C57BL/6 mice
Hello, I am C57BL/6 mice, is named the most commonly used inbred mice in the world . It is good to feed and live for a long time ( easy to keep, long life ), I do not know because of physical or paralyzed reasons, food is slightly tempted, it produces food-induced obesity and atherosclerosis . But fortunately, the incidence of cancer is not high, which is also a magic weapon for our longevity. I have been living for a long time and have been involved in many fields such as cardiovascular, developmental, diabetes, obesity, genetics, immunity, neurobiology, etc. Maybe the ear is not good, so it is not easy to have auditory epilepsy ! Immune checkpoints humanized mice are used by us!
DBA/2 mice
Hi, everyone, I am a DBA/2 mouse, always used to compare with C57BL/6 mice, very annoying. We don't eat as much as C57BL/6 mice. It is difficult for us to produce atherosclerosis through food temptation. When young, the asp mutation in the gene makes us poorly prone to hearing-induced epilepsy . When you are old, you will get a disease similar to human glaucoma . And there is no tolerance for alcohol and morphine . It’s just that, what's the point of living?

reference:

[1] http://

[2] Sérgio CA, Bertolini TB, Gembre AF, et al. CD11c+ CD103+ cells of Mycobacterium tuberculosis-infected C57BL/6 but not of BALB/c mice induce a high frequency of interferon-γ‐or interleukin‐17‐producing CD4+ cells [J]. Immunology, 2015, 144(4): 574-586.

[3] Costin BN, Dever SM, Miles M F. Ethanol regulation of serum glucocorticoid kinase 1 expression in DBA2/J mouse prefrontal cortex [J]. PloS one, 2013, 8(8): e72979.

[4] Makino S, Kunimoto K, Muraoka Y, et al. Breeding of a non-obese, diabetic strain of mice [J]. Experimental Animals, 1980, 29(1): 1-13.

[5] Bosma GC, Custer RP, Bosma M J. A severe combined immunodeficiency mutation in the mouse [J]. Nature, 1983, 301(5900): 527-530.

[6] https://

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