Pharmacological effects
1. The sedative effect of Xu Changqing extract (decoction and concentration, addition of alcohol to remove precipitate, which does not contain phytol) was injected intraperitoneally to the mice, which could significantly reduce the spontaneous activity of the mice, calm down, drooping eyelids, and still respond to external stimuli. , the role of sustainable more than 60 minutes. However, it does not prolong the sleep of barbiturates.
2, analgesic effect of the above extract to the mice intraperitoneal injection, analgesic effect occurred within 10 minutes, 60 minutes has not disappeared. Clinical studies have shown that paeonol is dissolved in peanut oil and made into injections to treat more than 20 cases of pain, with an effective rate of 83%. Among them, rheumatic arthralgia has good effect on renal colic, toothache and sella tumors. The analgesic effect of pain was satisfactory, but the pain caused by vasculitis and osteomyelitis was ineffective. The mouse hot plate test for pain test also showed that Xu Changqing had analgesic effect.
3. Effect on the cardiovascular system Xu Changqing can slow down the heart rate of normal animals. Electrocardiogram observation showed that rabbits were intravenously injected with Xu Changqing. Rats received intraperitoneal injection of prolonged RR intervals, and no significant changes in PR interval and T wave were observed.
Xu Changqing can significantly increase the uptake of Rb86 in the mouse myocardium, which can be considered to increase coronary blood flow, improve myocardial metabolism, and relieve myocardial ischemia. Continuous administration of Xu Changqing for 7 days could not prevent the change of acute myocardial hypoxia electrocardiogram induced by intravenous injection of pituitrin to rabbits.
Animal experiments show that Xu Changqing can lower blood pressure in dogs, rabbits, and rats. The use of Xu Changqing, which does not contain paeonol, can still rapidly and temporarily reduce blood pressure in anesthetized animals. Therefore, besides paeonol, Xu Changqing still contains other antihypertensive components.
4. Effects on blood lipids Xu Changqing has the effect of lowering serum total cholesterol and β-lipoprotein in experimental hyperlipidemia and experimental atherosclerosis model induced by cholesterol diet in rabbits, and can reduce aortic atherosclerosis. Hardening and deposition of small arterial lipids, indicating that Xu Changqing has a preventive effect on atherosclerosis.
5. Antibacterial effect Xu Changqing has inhibitory effects on Shigella and Staphylococcus aureus in vitro.
6, anti-inflammatory effect of paeonol sulfonic acid sodium on the rats full inhibition of formaldehyde swelling. Paeonol significantly inhibited the swelling of mouse ears caused by xylene and carrageenan, egg white, formaldehyde, histamine, 5-HT, and bradykinin caused rat paw edema; Toxin-induced increase in capillary permeability of the abdominal cavity.
7. Other experiments showed that paeonol had significant inhibitory effects on type II, III and IV allergic reactions. It does not significantly affect the formation of specific antibodies, but selectively inhibits the hemolytic activity of the classical complement pathway, as well as regulates cellular immune function. Paeonol has antioxidant effects and is more sensitive to calcium abnormal myocardial cells.
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