Sino-US research and development of nano vaccines against armor
Sino-US research and development of nano vaccines against armor
August 1, 2018 Source: Xinhua News Agency Author: Zhou Zhou
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According to Xinhua News Agency, Washington, July 30, Chinese and American researchers have jointly developed a nanoparticle flu vaccine that can effectively fight against influenza A virus in mouse experiments. This vaccine opens up new ideas for the development of drugs such as the universal influenza vaccine.
A recent study published in the Proceedings of the National Academy of Sciences shows that the particles are composed of bilayer polypeptides that mimic the influenza virus to emit biological signals that induce a double immune response. The researchers say that the core of the double-layer vaccine consists of a polypeptide in the influenza virus nuclear protein that induces immune T cell responses and cross-protects the influenza virus; the outer layer of the nanoparticles is made up of the M2 protein of the influenza A virus. Four peptides of the extracellular domain. In most human seasonal influenza viruses, the extracellular domain of this protein is a conserved region and is expected to become a target for future research on universal influenza vaccines. Wang Baozhong, an associate professor at the Institute of Biomedical Research at Georgia State University, said that the nanoparticles can also induce immune responses in B lymphocytes and synergize with immune T cells.
Studies have shown that mice vaccinated with multiple influenza A viruses survived completely after the vaccination, while mice vaccinated with placebo died within a week. The researchers believe that this two-layered peptide nanoparticle is more potent and more stable in its active ingredients, and is expected to be used in the development of other pathogens or cancer vaccines.
Polypeptides are intermediates in the process of protein hydrolysis and are much smaller than proteins. Wang Baozhong said that in terms of T cell immunity, only a small fraction of an antigenic protein is a valid antigenic determinant. Other sequences are not antigenic but may cause adverse reactions, while the use of peptides increases the density of effective antigenic determinants. And the polypeptide is easy to automate synthesis without complex protein expression and purification processes.
In the experiment, the vaccine was not inoculated using conventional intramuscular injection methods, but instead was inoculated on the skin using a soluble microneedle patch. The researchers say the method of administration is more potent and lasts longer. (Reporter Zhou Zhou)
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