Scientists find the key gene ZEB1 that controls brain tumor growth
Release date: 2017-03-13
Caption: A microscopic image of a brain cancer cell called a glioma tumor type of degenerative astrocytoma. From Wikimedia / CC BY-SA 3.0
Researchers at Cedars-Sinai have identified a stem cell regulatory gene that affects brain tumor growth and can strongly influence patient survival. The results, published in an online version of the Scientific Reports, will bring doctors closer to the goal: better predicting the prognosis of patients with brain tumors and developing more personalized treatments for them.
To enhance understanding of how glioma stem cells (GCSCs) multiply and how they affect patient survival, the researchers spent three years analyzing the genetic makeup of more than 4,000 brain tumors. During their investigation, they identified a gene that regulates tumor growth, called ZEB1. The researchers' analysis showed that patients with brain cancer without this gene often had lower survival rates.
Dr. John Yu, deputy director of the Department of Neurosurgical Oncology and deputy director of the Department of Neurosurgery, said: "The cancer in patients without this gene in the tumor is more aggressive and develops into an uncontrollable number of cell types." This new information can help us measure genetic mutations in these patients, enabling us to provide more accurate prognosis and treatment plans.
When cancer cells (also called malignant cells) appear in brain tissue, brain cancer occurs. This year, more than 23,000 people will develop primary cancerous tumors of the brain. According to the National Cancer Institute and the American Cancer Society, about 16,000 of these patients will die.
Yu and research colleagues point out that although some brain cancer patients do not have this gene at birth, others have, but over time, the genes have become less powerful – this may have a pathogenic effect.
"Compared with individuals with this gene, we found that survival in patients with mild gliomas with ZEB1 mutations was reduced by eight and a half months," said Yu, a co-director of neurological oncology at Cedars-Sinai. "We know that chemotherapy is ineffective in some people with gene deletions, so we have to treat with different drugs.
Source: Noble
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