Portable cytometer accelerates gene therapy 2.0 era
At the two sessions, the National People's Congress, the Standing Committee of the Taizhou Municipal Committee and the Secretary of the Party Committee of the Pharmaceutical High-tech Zone, Lu Chunyun mentioned in the "Recommendation on the inclusion of genetic testing in the reimbursement of special drugs for cancer", it is recommended to include targeted therapeutic gene testing in the scope of payment for cancer specific medicines. . The field of genetic testing, which greatly benefits people's livelihood, is also in full swing in the context of the continuous social system of policy dividends.
A few days ago, the MIT Science and Technology Review launched the “Top Ten Breakthrough Technologies in 2017†and “Gene Therapy 2.0†was among them. It is expected to usher in a new breakthrough this year. Gene therapy refers to the introduction of exogenous normal genes into target cells to correct or compensate for diseases caused by genetic defects or abnormalities, and ultimately achieve therapeutic purposes, with a history of more than 30 years. Although the process is quite rough, with the optimization of vector viruses and delivery mechanisms, gene therapy has entered the 2.0 era, showing a good prospect in the treatment of cancer and rare diseases.
Single cell sorting and sequencing docking device: "real-time" or even "portable" single cell sorting and sequencing
Recently, the microfluidic system team led by Ma Bo, a researcher at the Single Cell Research Center of the Qingdao Institute of Bioenergy and Processes, Chinese Academy of Sciences, has designed and implemented a simple and efficient single cell sorting and sequencing docking device to achieve one cell per tube. (One-Cell-One-Tube) is expected to serve single cell sorting and sequencing in "live", "real time" and even "portable". A method called "FOCOT" (abbreviation of Facile One-Cell-One-Tube) was invented, which is capable of separating, acquiring and dispensing a single microbial cell accurately, at a high speed and at a low cost, thereby directly docking with single cell sequencing.
The main features of the FOCOT platform are simple and convenient. The modular, compact and easy-to-use design makes the device suitable for carrying, assembling and using in the natural environment. It requires almost no additional personnel training and technical maintenance. It is especially suitable for scientific investigations for various extreme natural environments, and is also conducive to the promotion and application in general laboratories.
Portable instrumentation "gene therapy in a box"
How to achieve automated preparation of cells? This is the key to the Adair team's attempt to “popularize†gene therapy. They used a cell processing device, Prodigy, sold by German instrument manufacturer Miltenyi, which automates the key steps in gene therapy – cell preparation and amplification. The cells are input from one end of the instrument, and after 30 hours of operation, they are output from the other end, which can be used for treatment, which greatly shortens the cell processing time.
Adair hopes that this mobile instrument will extend gene therapy to more countries and the planet, including Africa, where the AIDS epidemic is most severe. In addition to Miltenyi, other research institutes and companies are actively developing similar cell processing equipment. For example, General Electric has acquired Biosafe, a company specializing in cell processing, and Draper Laboratories of MIT is developing a micro. Fluid equipment for pre-preparation of CAR-T therapy.
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