An international research team recently reported that they combined spider silk protein with silk fibroin to create a low-cost biocomposite that can be used as a wound dressing to promote healing and to replace natural skin for transplant surgery. Developed by researchers from the Royal Institute of Technology in Sweden and the Gauhati Campus of the Indian Institute of Technology, this material has shown good results in in vitro experiments and is about to be carried out in animal experiments.
Spider silk protein has high elasticity, high strength and excellent biological properties. The researchers used genetic modification to grow E. coli to produce recombinant spider silk protein. This protein combines natural substances in human skin, such as substances that promote cell binding, growth factors and antibacterial proteins, to promote skin cell growth. Recombinant spider silk protein is costly to produce and difficult to mass produce, and the researchers used it as a coating to combine with a substrate made of silk protein. Silk protein is not biologically active, but can be produced at low cost. The composite material thus obtained has both advantages, and can be used as a dressing in the form of a sheet, and can be a frame of artificial skin by forming a porous sponge.
Source: Beijing Daily
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