Metformin will begin to delay aging clinical trials
August 25, 2016 Source: US and Chinese medicine source
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, American doctor Nir Barzilai is preparing to start a clinical trial to delay aging, using the ancient diabetes drug metformin. The trial enrolled 3,000 elderly people, one with metformin and one with controls. Then observe the aging process. Since aging itself is not a disease, metformin here is strictly not a drug. Because the FDA only regulates food, medicine, and health care cosmetics, it is strictly not covered by the FDA. But Barzilai has communicated with the FDA and obtained FDA approval. This will be the first clinical trial to delay aging.
Longevity is an illusion that human beings have had since ancient times, but delaying aging is generally the site of the rivers and lakes. In a sense, aging is a necessary condition for the survival of species. Jobs said that death is the most important invention of life. Metabolism is essential for the survival and evolution of species. But Barzilai made it clear that his purpose was not to live forever, but to prolong healthy life and delay the onset of disease.
The pharmaceutical industry has also been eager to move around in this field. Since many animal experiments have found that many compounds can prolong the life of lower-grade animals, turning these observations into human effects has always attracted the attention of many people. The goal of Calico founded by Google last year was to delay aging. However, the development of such products is difficult. First how to define aging. Everyone's aging method is different. Barzilai is prepared to use the onset time of common chronic diseases such as heart disease, cognitive impairment, cancer, etc. as the therapeutic end point. Second, how to recruit test subjects. In theory, only healthy volunteers should be recruited because it is not intended to treat the disease. But how to define healthy volunteers in the elderly population is also a problem. In addition, delaying the onset of a single disease by a single mechanism is not a delay in aging. For example, the use of statins has been shown to delay the onset of cardiovascular disease, but statins are not aging drugs.
Therefore, aging is a combination of multiple factors, but the use of composite endpoints in clinical trials has many limitations in the development of single disease drugs. If cancer and senile dementia are used as a composite end point, it will inevitably bring many complicated factors to the analysis and clinical use of the experimental results. In addition, according to the efficacy of metformin, it is necessary to see the gap between the two groups for a long time, how to raise funds, how to ensure sufficient patent time, and how to profit in the end is also a problem. This test of metformin is only an academic study, but future commercial development will consider these issues.
If de novo development delays the safety of aging drugs is a huge obstacle. However, the safety of metformin has been verified by a long time and large population, so it is most suitable from a safety perspective. But the effect is a huge unknown. The most reliable effect of metformin is blood sugar lowering, but in addition to the SGLT2 inhibitor Jardiance, there are no other drugs that can delay the onset of cardiovascular disease in large clinical trials, let alone delay aging. But this experiment is, after all, the first clinical trial to delay aging, and even if it is not successful, it can provide some valuable experience. Aging is the biggest risk factor for most diseases, and delaying aging is the most effective tool for controlling medical expenses.
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