Crazy T cells tell you why you have type 1 diabetes
Type I diabetes is a serious autoimmune disease that jeopardizes the health of millions of people around the world. Once diagnosed, patients need insulin therapy for life and face a number of complications. The most important thing about type 1 diabetes is that T cells in the immune system have begun to attack beta cells that produce insulin before clinical symptoms appear. When the clinical symptoms appear, most of the beta cells have been hung.
In the early stages of the type 1 diabetes study, the researchers thought it was a disease that occurred in children and adolescents, but later found that many adult patients diagnosed with type 2 diabetes were actually type 1 diabetic patients. This makes type 1 diabetes more mysterious. It has been found that genetic variation, viral infection, and intestinal microbial imbalance are associated with the onset of type 1 diabetes. Even studies have shown that the incidence of type 1 diabetes is related to the season and the month of birth. For example, the number of people diagnosed with diabetes in the fall and winter is significantly higher; the risk of developing type 1 diabetes in the spring is higher.
But knowing that this does not seem to help much in the prevention and treatment of type 1 diabetes, the academic community still does not know when it happened or how it started. This is a disease in which "the dragon is not seen at the end".
Recently, the Ezio Bonifacio team from the Dresden University of Technology has undergone nearly 20 years of research and finally found important findings, and their research is very likely to change the situation.
Yale University endocrinologist Kevan Herold believes that the work of the Bonifacio team is unconventional and they are very likely to find a way to diagnose type 1 diabetes earlier than current diagnostic methods. Obviously this study is significant, and if it is proven in a wider range of children, the diagnosis and prevention of type 1 diabetes will change dramatically. The results of the Bonifacio team's research were published in the cover of the famous journal Science Translational Medicine.
Red antigen presenting cells are activating T cells (white and blue)
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