Chinese researchers based on acupuncture therapy found a therapeutic target for bronchial asthma
Release date: 2018-02-27
Inspired by acupuncture and moxibustion treatment, Chinese researchers first discovered and verified a therapeutic target for bronchial asthma, which provided ideas for the development of new drugs. Relevant results have recently been published as a cover article in the international academic journal Science·Transformation Medicine.
Image source: Science Translational Medicine
This article is reproduced from the "Xinhua News Agency", the original title: Chinese researchers based on acupuncture therapy to find new targets for asthma treatment.
Asthma is a common chronic respiratory disease that seriously threatens human health. The pathological mechanism is still inconclusive. Acupuncture treatment of asthma is a summary of the experience of traditional Chinese medicine, and its principle has always been the subject of research by scientists.
According to one of the authors, Professor Deng Linhong from Changzhou University, the study found that after acupuncture at Dazhui, Fengmen, Feishu and other acupoints, not only the respiratory function of asthma patients was significantly improved, but also the metallothionein-2, which plays a key role in relieving asthma. The MT-2) content has also increased. Further studies have shown that the receptor for MT-2 on airway smooth muscle cells is actin-binding protein-2 (Transgelin-2).
“Transgelin-2 is the first new target for the treatment of bronchial asthma discovered and validated by Chinese researchers based on acupuncture therapy.†Deng Linhong said that the researchers screened nearly 6,000 compounds and found that the lead compound TSG12 can also effectively relax airway smooth muscle cells. It reduces the airway resistance and acts like acupuncture, which is expected to become a new drug for the treatment of asthma.
Source: Xinhuanet
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