In January 2005, US President Barack Obama publicly stated that the United States should conduct precision medical research. Since then, precision medicine has received widespread attention around the world. At present, precision medical research has become the commanding height of a new round of national science and technology competition and leading international strategy. In addition to the United States, the European Union is actively promoting research on so-called precision medicine, and Japan is also investing in plans related to precision medicine. Our national leaders have also given important instructions on the development of precision medicine many times, and they also have concrete manifestations in funding.

So, what is the essence of precision medicine, and what is the core? I personally feel that the core of precision medicine is actually a point, that is, the combination of big data and medicine in group learning, to be more specific, is the combination of group big data and clinical medicine. In other words, the use of group big data in clinical medicine to improve the accuracy of medical diagnosis and improve the effectiveness of treatment.

This includes two meanings, one meaning big data for group learning, and the other meaning is medicine. among them. The big data of omics includes two meanings, one is omics and the other is big data. We know that in recent years, with the development of clinical research, we have acquired more and more human information at the molecular level represented by the genome, which is unprecedented. With the development of omics data represented by the genome, more and more people are accumulating information such as genetic information represented by the genetic code, including protein information. Later, people discovered that after mining this information, they will get a lot of information reflecting human health and disease. Therefore, it has been suggested that if this information is applied to the clinic, it will definitely improve the clinical effect. This is the essential meaning of precision medicine.

However, it is not enough to obtain only the information of these genetic codes. As you know, all genetic code information is a very large amount of big data. This big data is very easy to measure, but if you understand it, you should develop the theoretical methods and techniques of big data analysis. Therefore, to use these omics data in large clinical practice, it must be a combination of omics data and big data analysis methods. Therefore, part of it is group data and part of it is medicine. The combination of the two forms the essence and core of precision medicine.

Academician Chen Runsheng

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