"Wan Jian Qi Qi" makes the tumor nowhere to escape

Malignant melanoma is a kind of skin cancer with high malignancy and easy to metastasize. Traditional chemotherapy and radiotherapy are not ideal for melanoma. Therefore, early diagnosis and treatment of malignant melanoma can improve the quality of life and cure of patients. The rate is crucial. With the rapid development of nanotechnology, the new nanoprobes can integrate the functions of diagnosis and treatment of tumors, not only to achieve multimodal imaging of tumors, but also to achieve multi-modal synergistic therapy, and even multimodal imaging guidance. Mode treatment.

Professor Huang Peng's research group of the School of Biomedical Engineering of Shenzhen University School of Medicine and Professor Li Zhiming's research group of Wenzhou Medical University and other units have made important progress in the integration of malignant melanoma and treatment. The team co-loaded the near-infrared fluorescent dye indocyanine green (ICG) and the chemotherapeutic drug 5-fluorouracil (5-FU) onto silica-coated gold nanorods to successfully construct a nanomedicine carrier for integrated diagnosis and treatment. The nano drug has the characteristics of absorption spectrum controllability, high drug loading, pH and laser-regulated drug release, high chemical stability and high biocompatibility. Studies have shown that the nano-drug can be efficiently enriched in the tumor site, increasing the concentration of 5-FU in tumor tissue by 10 times. More valuable is the intelligent controlled release of chemotherapeutic drugs through dual changes in pH and laser irradiation. At the same time, the near-infrared fluorescence and photoacoustic imaging of melanoma are realized by the near-infrared fluorescence characteristics of ICG and the photothermal effect of gold nanorods, which improves the accuracy and sensitivity of tumor imaging diagnosis. In addition, using the photosensitivity effect of ICG and the photothermal conversion effect of gold nanorods and the release of 5-FU, the three-mode synergistic treatment of tumor photothermal, photodynamic and chemotherapy is simultaneously achieved. This multimodal imaging-guided multi-modal treatment, like "ten arrows", leaves the tumor in nowhere. The research provides a technical platform and solution for molecular imaging, precision therapy, synergistic therapy, and integration of diagnosis and treatment of tumors.

The research results were published in "Small" in the form of a cover article.

Http://onlinelibrary.wiley.com/doi/10.1002/smll.201602580/full