US scientists have found a new way to transport cells "fuel" to help develop new drugs for chronic diseases in the elderly
January 9, 2019 Source: Science and Technology Daily Author: Liu Haiying
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Researchers at the University of Washington School of Medicine published a paper in the journal Nature and Metabolism on the 7th that a transporter called Slc12a8 plays an important role in the cellular energy supply chain, and can directly transport the fuel needed for cell metabolism. Into the cells. The researchers pointed out that the discovery of this new path of cellular fuel delivery can help reveal the human aging process and its associated chronic disease pathology, and thus help develop new therapeutic drugs to reduce the adverse effects of the passage of time.
Nicotinamide adenine dinucleotide (NAD) molecules play an important role in a variety of cellular metabolic reactions and are important supports for cell viability. However, as we age, the level of NAD will continue to decrease and the ability to metabolize cells will be affected. Although scientists have discovered that cell production of NAD begins with a precursor molecule called nicotinamide mononucleotide (NMN), it remains unclear how this precursor molecule enters the cell and is processed into NAD.
This time, researchers at the University of Washington found the answer to this puzzle. They conducted multiple experiments in cells and mice and finally discovered the delivery mechanism of NMN. Studies have shown that the Slc12a8 protein transports NMN directly into cells with the help of sodium ions and plays a rapid role in the production of NAD. When the level of NAD declines, the cells also enhance the expression of the Slc12a8 gene and increase their ability to transport NMN.
The researchers point out that the discovery of NMN delivery mechanisms is important to help scientists find ways to increase the supply of energy to aging cells. Past studies have shown that taking NMN in elderly mice is beneficial to their systemic metabolism, and has a positive impact on skeletal muscle, liver function, bone density, ocular function, insulin sensitivity, and immune function. The new study suggests that strategies that complement NMN and stimulate MMN transporters may help older people maintain cellular energy and alleviate chronic disease-related symptoms. Currently, researchers have identified small molecules that enhance the function of NMN transporters and work with pharmaceutical companies to develop new therapies for chronic diseases in the elderly.
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