There is a causal relationship between adequate sleep and cardiovascular health

There is a causal relationship between adequate sleep and cardiovascular health

February 18, 2019 Source: Science and Technology Daily Author: Zhang Meng Ran

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According to a medical research paper published online by the British journal Nature recently, American scientists describe the mechanism by which sleep affects the risk of atherosclerosis (intra-arterial plaque build-up) in mice. This new finding suggests a causal relationship between adequate sleep and cardiovascular health.

Atherosclerosis is a common cause of heart disease. Insufficient sleep or poor sleep quality is associated with multiple health conditions, including an increased risk of heart disease. However, researchers know little about the cellular mechanisms and molecular mechanisms that sleep can affect cardiovascular health.

This time, Philip Swesky, a researcher at the Massachusetts General Hospital and Harvard Medical School, and colleagues studied long-term sleep fragmentation (sleep disruption or lack of sleep) for genetically modified mice that are susceptible to atherosclerosis. influences. The team reported that long-term sleep fragmented mice were more anxious than control mice, produced more inflammatory cells, and formed larger atherosclerotic plaques. The orexin peptides (a neuropeptide that regulates wakefulness) produced by the lateral hypothalamic regions of these mice are also less.

The researchers explained that the orexin controls the production of blood cells, including immune cells, through a signaling protein called CSF1. They observed that in mice with insufficient sleep, the production of immune cells increased and atherosclerosis accelerated. They believe that this is caused by a decrease in orexin and an increase in CSF1 levels. Restoration of the orexin levels in these mice reduced atherosclerosis.

The next step is to test whether these findings are also present in humans. In the accompanying news and opinion articles, the researchers believe that undisturbed sleep can maintain proper release of the orexin peptides in the hypothalamus and protect cardiovascular health.

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