On December 6, 2005, the results of the project “Using Rape Oil Body Expression System to Produce Salmon Calcitonin†completed by the Institute of Biotechnology of the Chinese Academy of Agricultural Sciences passed the expert appraisal. This achievement was supported by the National 863 Plan Bioreactor Major Project. Mr. Shi Yanquan, Deputy Director of the Department of Science and Education of the Ministry of Agriculture, presided over the appraisal meeting. Deputy Director of the Dao Daochang Biotechnology Development Center of the Ministry of Science and Technology, Director Jiang Maosen and Director Wang Zhen of the Department of Agricultural Sciences and Technology of the Ministry of Science and Technology, Director Chen Zhaobo of the Rural Center of the Ministry of Science and Technology, and the Ministry of Science and Technology Li Qing, Director of Biotechnology Development, and Director Wang Deping, the President of the Chinese Academy of Agricultural Sciences, Quhu Canal, and Deputy Director Lei Maoliang, as well as the leaders of the Science and Technology Administration and Biotechnology Institute of the Academy of Sciences, attended the appraisal meeting. An appraisal committee composed of experts such as Prof. Qunqin Qin, Academician Fang Rongxiang, and Prof. Shen Peifen carefully listened to Dr. Liu Yuhui’s comprehensive study report, carefully reviewed relevant technical data, and through inquiries and serious discussions, agreed that the results were the first to use plants. The bioreactor expresses the biologically active salmon calcitonin protein at high levels in the oil body of the transgenic rapeseed and created a complete set of technical systems. The overall level of the bioreactor is internationally leading to the large-scale production of calcium in the future using plant bioreactors. Protein and other medical proteins provide a technical platform and have achieved important innovations in the following areas: 1. The promoter and oleosin structural gene of oleosin gene of rape oilseed protein were isolated and cloned and synthesized according to plant-preferred codons. The salmon calcitonin mutant gene msCT was used to construct a plant expression vector that can efficiently express the Oleosin-msCT fusion protein gene in rape seeds. 2. Established and optimized an efficient genetic transformation system for rape, with a frequency of 12.5%. 3. Through stringent detection and screening of transgenic rapeseed and its progeny, a pure line of T5 transgenic rape which expresses salmon calcitonin highly efficiently was obtained. The expression of fusion protein accounted for 6.47% of total seed protein, which was significantly higher than other proteins reported in the literature. Expression levels in oilseed rape. 4. The rat tail vein injection and osteoclast test showed that the salmon calcitonin expressed in rapeseed oil has high biological activity (about 1700 IU/mg). Transgenic rape seeds were stored at room temperature for 16 months and oil protein was extracted. After the tail vein injection, the blood calcium concentration of rats was still significantly reduced. The appraisal committee recommends that relevant state departments continue to support and increase input, and further strengthen the research and development of separation and purification processes, dosage forms and clinical and other downstream application technologies, and promote and accelerate the transformation of this result. The oil body expression system is a new technical system for the expression and production of foreign proteins. It has the advantages of high expression of target protein, simple extraction process, and easy separation and purification. It can express 3 mg of salmon calcitonin per gram of rape seed. Using the lipophilic hydrophobic nature of the oil body, the seeds were crushed-centrifuged-recovered from the upper oil phase-deoiled to obtain a fusion protein. The use of genetically modified plants to produce expensive medical or industrial proteins, with low production costs, can greatly increase the added value of agricultural and sideline products, and has a huge market application prospects. Related information: Calcitonin (CT) is an important small-molecule polypeptide drug for the treatment of osteoporosis, deformed osteitis, bone pain, etc. It has a lower blood calcium concentration and inhibits the formation of osteoclasts. The role of the treatment of osteoporosis has a significant effect, the clinical application of nearly 30 years, the current international market sales of 700 million US dollars, the original drug price of 18,200 yuan / gram. Osteoporosis is a serious threat to human health. According to statistics, the bone density of Chinese people is 8% lower than that of Westerners. The incidence of osteoporosis in the elderly over 60 years of age in China is 60%. Each year, osteoporosis causes fractures. About 9.6%. There are approximately 1.7 million cases of femur fractures in the world each year. With the increase of aging, it is estimated that by the year 2050, there will be 6.4 million people suffering from femoral fractures each year, of which 51% will occur in Asia.
LED Red Light Therapy Machine
What's red light therapy? Red light therapy before and after
Red light therapy (RLT) is a treatment that may aid in the healing of skin, muscle tissue, and other body components. It exposes you to red or near-infrared light at modest intensities. Infrared light is a sort of energy that your eyes cannot see but which your body perceives as heat. Red light is comparable to infrared light, however it is visible.
Low-level laser treatment (LLLT), low-power laser therapy (LPLT), and photobiomodulation are all terms for red light therapy (PBM).
What Is Red Light Therapy and How Does It Work?
Red light treatment involves exposing your skin to a red-light bulb, gadget, or laser. Mitochondria, also known as the "power generators" of your cells, absorb it and use it to produce additional energy. This, according to some scientists, helps cells repair themselves and grow healthier. This promotes skin and muscular tissue repair.
The skin is not injured or burned by red light treatment since it employs very low amounts of heat. It is not the same sort of light used in tanning salons, and it does not expose your skin to UV rays that are harmful to your skin.
What Is It Used For?
Red light treatment has been studied for a long time. However, there aren't many research on it, and no one knows if it's better than other sorts of healing treatments. The use of red light therapy may be beneficial in the following situations:
Dementia. People with dementia who received near-infrared light treatment on their heads and via their nostrils on a daily basis for 12 weeks had improved memory, slept better, and were less irritable.
Pain in the teeth. People with temporomandibular dysfunction syndrome (TMD) experienced decreased discomfort, clicking, and jaw soreness after receiving red light treatment, according to another small study.
Hair loss is a common occurrence. In one research, men and women with androgenetic alopecia (a hereditary condition that causes hair loss) gained thicker hair after using an at-home RLT device for 24 weeks. The outcomes were not the same for those who utilized a bogus RLT gadget in the trial.
Osteoarthritis. According to one research, red and infrared light treatment reduced osteoarthritis-related pain by more than half.
Tendinitis. RLT appears to reduce inflammation and discomfort in persons with Achilles tendonitis, according to a small trial of seven participants.
Wrinkles and other symptoms of aging and damage to the skin. RLT has been shown in studies to aid with wrinkles and skin smoothing. RLT can also assist with acne scars, burns, and sun damage indications.
What Are the Consequences?
Even though experts aren't clear how or why red light treatment works, it's usually thought to be safe. There are also no hard and fast guidelines on how much light to use. Too much light can harm skin tissue, while too little can make it less effective.
What Is Red Light Therapy and Where Can You Get It?
At most cases, it's done in a doctor's office. Some salons and dentistry clinics, however, do it as well. You may also purchase a red light treatment gadget on your own. Side effects and injuries are more likely to occur with salon and at-home treatments. If you're considering red light treatment, see your doctor first.
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