On the 10th, the reporter learned from Wuhan University that the basic medical unit of Wuhan University and the Zhongnan Hospital of Wuhan University were the main completion units. The project “Building and Application of the Innovation System for Fetal Diseases†lasted for 22 years, based on the first series. Intrauterine growth retardation and fetal-derived disease models have established a complete set of innovative theory and research system for fetal-borne diseases, and are effectively used for risk assessment and early warning of fetal-borne diseases. This achievement has filled the gap in the field of international research on fetal diseases and has enhanced China's international competitiveness and influence in this research field.
Wang Hui, the chief scientist of the project and director of the Department of Pharmacology at the Basic Medical College of Wuhan University, introduced that the project first established a model of intrauterine growth retardation caused by exposure of a series of exogenous substances during pregnancy, confirming the multi-target direct toxicity of exogenous substances. To elucidate its in situ metabolic damage and epigenetic mechanism, and to find the intrauterine maternal glucocorticoid overexposure and its "frugal phenotype" programming mechanism in the adverse environment during pregnancy.
“At the same time, the project used the 'two strikes' method for the first time to construct a variety of fetal disease models, including metabolic syndrome, nonalcoholic fatty liver, hypercholesterolemia, diabetes, osteoarthritis, osteoporosis, kidney. Small ball sclerosis, bipolar disorder, etc., and for the first time in these models of fetal disease, confirmed the 'two programming' mechanism of intrauterine maternal glucocorticoids, pointing out that the core is 'glucocorticoid-insulin-like growth Factor 1 axis 'programming changes.'" Wang Hui said.
It is noteworthy that the project also comprehensively proposes an early comprehensive prevention and treatment strategy for fetal-derived diseases, and establishes a risk assessment technique for intrauterine growth retardation based on differences in maternal blood metabolism profiles, and a variety of genetic markers based on umbilical cord development-related genes. Early warning technology for fetal diseases, and confirmed that the traditional Chinese medicine Angelica ingredients - sodium ferulate and angelica injection can effectively prevent intrauterine growth retardation caused by exposure to tobacco and alcohol during pregnancy, Angelica polysaccharide and licorice polysaccharide can effectively prevent osteoarthritis. (Reporter Ma Aiping)
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