Chinese scientist CellStem Cell issued a document: revealing the key pathways of stem cell microenvironment affecting cell regeneration ability
January 11, 2019 Source: Ministry of Science and Technology
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];In August 2018, Cell Stem Cell magazine reported on the molecular mechanism of the Beijing Institute of Bioscience Research on how the heterogeneity and plasticity of the stem cell microenvironment affects stem cell regeneration, and found that the Hoxc gene is in the stem cell microenvironment. Differential expression can cause activational changes in the downstream Wnt signaling pathway, resulting in a positional difference in hair follicle stem cell regeneration in different parts of the skin of the mouse.
To explore the molecular mechanisms of region-specific hair regenerative capacity, the researchers first used flow cytometry (FACS) to isolate the ear and back of wild-type mice and the ear of the hairy mutant Koa (Koa). Epidermal cells and dermal cells, high-throughput sequencing of RNA revealed that the Hoxc gene near the Koa breakpoint was highly expressed in the dermis of the wild type mouse and the dermal cells of the Koa ear, but not in the ear of the wild type mouse. . Next, the researchers demonstrated that the Hoxc gene is mainly expressed in dermal papilla cells by means of in situ RNA. After knocking out nine Hoxc genes on the Koa chromosome using the CRISPR/Cas9 technology, it was found that the hairy phenotype of Koa disappeared. However, if only a single Hoxc gene is knocked out, the hairy phenotype of Koa cannot disappear or disappear completely, which proves that the Hoxc gene family is responsible for the hairy Koa.
In addition, the researchers also found that the Wnt signaling pathway is involved downstream of the Hoxc gene, and the mutation of Rspo2, which is activated by Hoxc downstream of the Wnt signaling pathway, leads to hair loss. Therefore, the research team will further explore the cellular and molecular mechanisms of human hair development and evolution.
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