Chinese Factory Supply Bivalirudin (128270-60-0)

Quick Details
 
Description

Bivaroxaladine is a direct inhibitor of thrombin, and it inhibits the specific binding of free and thrombolytic thrombin catalysis sites and anion extracellular binding sites. The binding process between bevaludin and thrombin is reversible, and thrombin can restore the original biological activity of thrombin by slowly enzymatic hydrolysis of the peptide bond between Arg3 and Pro4 of bevaludin.
Than cutting luding in vitro studies have shown that not only can side free thrombin, suppression can inhibit thrombin and combined with blood clots will not be platelets release material and, it can prolong normal plasma activated part of prothrombin time (APTT), thrombin time (TT), prothrombin time (PT) and activated clotting time (ACT), and has a linear relation with concentration than cutting luding, but the clinical application of whether there is the correlation is unclear.
Matters needing attention
Bivaroxadine cannot be used for muscle injection.
Bleeding: unexplained erythrocyte volume, hemoglobin or blood pressure drop may indicate bleeding and should be discontinued if bleeding or suspected bleeding occurs. No detoxification drug has been found, but its effects will soon disappear (t1/2 is 35-40 min).
Allergy: if the patient has urticaria, systemic urticaria, chest tightness, wheezing, hypotension and allergic reaction, the patient should be informed in advance. In the case of shock, the current treatment method should be used. There have been few clinical reports of deaths from allergies and allergies since the launch (see adverse reactions). For patients who have previously been treated with bevaludin, antibody production should be noted. Patients receiving close - range radiation therapy using bifenugreek timing have an increased risk of thrombosis and even death.
ACT should be monitored in patients with renal impairment.
  Quick Details
 
Description

Bivaroxaladine is a direct inhibitor of thrombin, and it inhibits the specific binding of free and thrombolytic thrombin catalysis sites and anion extracellular binding sites. The binding process between bevaludin and thrombin is reversible, and thrombin can restore the original biological activity of thrombin by slowly enzymatic hydrolysis of the peptide bond between Arg3 and Pro4 of bevaludin.
Than cutting luding in vitro studies have shown that not only can side free thrombin, suppression can inhibit thrombin and combined with blood clots will not be platelets release material and, it can prolong normal plasma activated part of prothrombin time (APTT), thrombin time (TT), prothrombin time (PT) and activated clotting time (ACT), and has a linear relation with concentration than cutting luding, but the clinical application of whether there is the correlation is unclear.
Matters needing attention
Bivaroxadine cannot be used for muscle injection.
Bleeding: unexplained erythrocyte volume, hemoglobin or blood pressure drop may indicate bleeding and should be discontinued if bleeding or suspected bleeding occurs. No detoxification drug has been found, but its effects will soon disappear (t1/2 is 35-40 min).
Allergy: if the patient has urticaria, systemic urticaria, chest tightness, wheezing, hypotension and allergic reaction, the patient should be informed in advance. In the case of shock, the current treatment method should be used. There have been few clinical reports of deaths from allergies and allergies since the launch (see adverse reactions). For patients who have previously been treated with bevaludin, antibody production should be noted. Patients receiving close - range radiation therapy using bifenugreek timing have an increased risk of thrombosis and even death.
ACT should be monitored in patients with renal impairment.
 

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